She started her screen career appearing on television shows such as My Wife and Kids (2003), Joan of Arcadia (2004), What About Brian (2007) and CSI: Miami (2007).She gained recognition in 2007 with her breakthrough role as Vanessa Abrams on The CW's teen drama series Gossip Girl (2007–12).In November 2011, Szohr filmed the drama Light Years in Los Angeles.In 2012, Szohr helped Hayden Panettiere punk Glee actress Dianna Agron.He also had a minor role in the film Children of Men (2006). I needed to be on set, in front of the camera." In 2007, Westwick appeared in the film Son of Rambow and was cast as Chuck Bass in The CW's teen drama series Gossip Girl, based on the book series of the same name by Cecily von Ziegesar.
All of the alleged incidents are claimed to have occurred in 2014.
That same year, he appeared as Joey in the horror film 100 Feet.
In 2009, Westwick played the role of Randy Jackson in the sequel to Donnie Darko, directed by Chris Fisher, and guest-starred in the third season of the Showtime original series Californication, as Chris "Balt" Smith, a student who was fascinated with vampire literature.
In June 2015, Szohr was set as a recurring on the upcoming second season of Direc TV’s MMA drama Kingdom.
Szohr will play Laura Melvin, an artist/photographer who has "read everything, been everywhere," and immediately intrigued by Jay (Jonathan Tucker) whom she wants to hire for a photo shoot.