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Medical device manufacturers employ 9,757 residents. Major hospital employers include the Cleveland Clinic Health System with 41,400 employees, Catholic Healthcare Partners in Cincinnati with 28,200, University Hospitals of Cleveland with 21,800, Ohio Health in Columbus with 15,300, Pro Medica in Toledo with 14,500, and Premier Health Partners in Dayton with 14,000.Welltower, an S&P 500 company headquartered in Toledo, is a major healthcare real estate firm.

Biotech research and development employs directly 12,415 residents, while agricultural bioscience contributed the largest economic impact, at .7 billion.Other Ohio cities listed include Cincinnati at #6 and Cleveland at #16. News and World Report ranked the clinic as the fourth best hospital in the country, and the #1 heart center in the country for the 15th year in a row.Ohio is home to world class medical facilities, led by the Cleveland Clinic, which has locations throughout the world. Overall, the magazine ranked 16 Ohio hospitals among the best hospitals in the nation, making the state #3 in the country in total. News and World Report, in 2010, Health Grades ranked nine Ohio hospitals in the top 50 in the United States University Hospitals Case Medical Center in Cleveland was named in the top 15 for major teaching hospitals, while Riverside Methodist Hospital in Columbus and Hillcrest Hospital in Mayfield Heights ranked in the top 16 for minor teaching hospitals.A new report by the Quantitative Economics and Statistics Practices (QUEST) of Ernst & Young in conjunction with the Council On State Taxation (COST), ranks Ohio as third in the nation for friendliest tax environment.The study, "Competitiveness of state and local business taxes on new investment," provides a state-by-state comparison of tax liabilities.RTI International Metals's location in Niles produces titanium used in every France-based Airbus aircraft.RTI was originally headquartered in Niles before moving to Pittsburgh in the 21st century, while Airbus has invested .3 billion in the state.The United States Department of Defense currently maintains a large Supply Center in Whitehall, a suburb of Columbus.Wright-Patterson Air Force Base, located in Dayton, and partially named for the Wright Brothers from Ohio who are generally credited with inventing the airplane, employs 27,400 residents.The Air Force estimates that Wright-Patterson’s annual economic impact on the Dayton region is .1 billion.Ohio had three city-regions in the top 30 biotech locations in the country, with Cleveland-Akron ranked #20, Columbus #22, and Cincinnati #28.

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